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Can Polynucleotide Treatment Really Help with Hair Loss?

Updated: Apr 27

Pattern hair loss, which is another name for androgenetic alopecia, is the most common cause of hair loss on the head in both men and women. Scalp hair follicles gradually get smaller, and the disease shows up differently in men and women. It's mostly caused by an enzyme called 5-α-reductase changing testosterone to dihydrotestosterone, which is a more potent androgenic form. 

Because androgenetic alopecia makes people change in ways that can be seen, it can cause serious mental health problems.

Treatment is often hard because the condition lasts for an extended period and is caused by genetic and environmental factors. Finasteride and minoxidil are two mainstays of long-term treatments. (1) Minoxidil applied to the skin and finasteride taken by mouth are the only treatments approved by the FDA. However, there are many other treatments that have been suggested in the literature. These include platelet-rich plasma (PRP), mesenchymal stem cell exosomes, micro-needling, nutraceuticals, and customised dietary supplementation with certain micronutrients and vitamins.

Recent studies have shown that nutrients from the sea might help treat androgenetic alopecia in both men and women. Polynucleotides injected under the skin, on the other hand, have been shown to help hair follicles heal and may even help hair grow.

The point of this blog was to look at the data again with a wider view and see if polynucleotide injections could treat both male and female pattern androgenetic alopecia safely and effectively.

Polynucleotides are DNA molecules that were taken from the gonads of male salmon fish using advanced methods of purification and high-temperature sterilisation.

People who work in cosmetic medicine have used polynucleotide on its own, with hyaluronic acid, or with a CO2 laser to treat stretch marks. Polynucleotide was useful in several clinical tests for treating venous ulcers in the lower limbs, atrophic vaginal lips in women after menopause, and osteoarthritis in the knee by injecting the joint.

Twenty individuals with mild to moderate androgenetic alopecia were invited to participate in the recent clinical trial. Polynucleotides were injected for 10 sessions over 4 months. 

The average age was 37 years, with a standard deviation of 8 years. The results revealed that, 63% of patients experienced some change in hair growth after 4 months of treatment. There was a statistically significant decrease in hair loss at all visits. Additionally, by week 24, there was a statistically significant increase in the average thickness of the hairs.

85% of participants reported that their hair looked "better" after 4 months. No severe side effects were reported. Two patients experienced a mild headache, two reported mild swelling, and two had a mild rash. All symptoms resolved on their own within a few days. (2)


This study demonstrates that polynucleotide injection is an effective method for treating hair loss and increasing hair thickness on average, with high patient satisfaction and a low risk of side effects in both men and women with androgenetic alopecia.

Polynucleotide for hair loss before and after
Polynucleotide for hair loss before and after





1.      Gupta AK, Wang T, Bamimore MA, Talukder M. The relative effect of monotherapy with 5-alpha reductase inhibitors and minoxidil for female pattern hair loss: A network meta-analysis study. J Cosmet Dermatol. 2023 Jun 29.

2.      Samadi, Aniseh & Ayatollahi, Azin & Nassiri-Kashani, Mansour & Zamani, Shayan & Firooz, Alireza. (2023). Efficacy and tolerability assessment of a polynucleotide‐based gel for improvement of pattern hair loss Running title: A polynucleotide‐based gel for improvement of pattern hair loss. 10.21203/

Read more about polinucleotides here

Check with Skinoza team to see how well you are handling the polynucleotide treatment so you understand what can be done with it. This is all about helping you stay safe and at less of a risk of serious problems when using these.

Ask your trusted Skinoza clinic today for the procedure that suits you! Find Polynucleotide Treatment Near You:

1. Skinoza Orpington, Bromley near Chislehurst, Bickley, Beckenham, West Wickham, Sidcup and Swanley

2. Skinoza Greenwich near Canary Warf, Deptford, Surrey Quays and Kidbrooke Village

3. Skinoza Blackhorse Road, Walthamstow near Tottenham Hale and Seven Sisters

We are experts in polynucleotide treatment for hair loss in London

Please feel free to get in touch for a free consultation and start your journey towards enhanced beauty.


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